Fat accumulation and its consequences due to fructose

Natural fructose is a useful source of energy in small doses. Fructose that has been artificially added to beverages and other foods is harmful to human health. In larger quantities, it metabolises in the liver, forming lipid droplets that enter the bloodstream as well as deposits in the liver. This fatty conversion is known as de novo lipogenesis. Excess fat accumulates in adipose tissue and internal organs. Obesity develops in the central region of the body. Fructose also contributes to the development of insulin and leptin resistance, ultimately leading to weight gain and obesity. Fructose speeds up the maturation of preadipocytes and enhances fat storage capacity.

Muscle cells, which consume the majority of the blood glucose as an energy source. Insulin resistance causes cells to starve for energy because they are unable to take up enough glucose. Lack of energy signals the brain to stimulate the hunger center. Insulin resistance causes cells to starve for energy because they are unable to absorb enough glucose. Lack of energy signals the brain to stimulate the hunger center. Similarly, leptin resistance reduces the signals to the satiety center. As a result, these acts enhance food consumption. It raises the blood sugar level. This vicious cycle of insulin and leptin resistance can lead to weight gain, obesity, and eventually, type 2 diabetes. The constant elevation of blood sugar levels can also increase the risk of cardiovascular disease and other health complications. Therefore, it is crucial to address insulin and leptin resistance through a balanced diet, regular exercise, and other lifestyle modifications to prevent these serious health issues.